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Rational polytherapy in the treatment of refractory epilepsy has been the main therapeutic modality for several years. Furthermore, this model might be appropriate for studying the unrevealed mechanism of ictogenesis.Ī Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy.Īndres-Mach, Marta Zagaja, MirosÅ‚aw Haratym-Maj, Agnieszka Rola, RadosÅ‚aw Maj, Maciej Haratym, Joanna Dudra-JastrzÄ™bska, Monika Łuszczki, Jarogniew J These findings should be considered when performing in vivo studies using this animal model. The seizure-free periods between clusters were long. We demonstrate that almost all seizures occur in clusters with a cyclic pattern in the chronic stage of a mouse pilocarpine-induced epilepsy model. The SRSs also occurred in a grouped pattern within a day. The seizure clusters were followed by long seizure-free periods of 16.3Â☖.8 days, showing a cyclic pattern. Every mouse displayed seizure clusters, and 97.0% of the seizures occurred within a cluster period. The video-EEG monitoring began 84.5Â☓3.7 days after the induction of SE and continued for 53.7Â☒0.4 days. We analyzed the cluster duration, seizure-free period, cluster interval, and numbers of seizures within and outside the seizure clusters.

A seizure cluster was defined as the occurrence of one or more seizures per day for at least three consecutive days and at least five seizures during the cluster period. In this study, we investigated the detailed characteristics of seizure clustering in the chronic stage of a mouse pilocarpine-induced epilepsy model for an extended duration by continuous 24/7 video-EEG monitoring. However, most studies have analyzed seizures for a short duration after the induction of status epilepticus (SE). The clustering of spontaneous recurrent seizures (SRSs) in animal models of epilepsy, including mouse pilocarpine models, has been reported. Seizure clustering is a common and significant phenomenon in patients with epilepsy. Lim, Jung-Ah Moon, Jangsup Kim, Tae-Joon Jun, Jin-Sun Park, Byeongsu Byun, Jung-Ick Sunwoo, Jun-Sang Park, Kyung-Il Lee, Soon-Tae Jung, Keun-Hwa Jung, Ki-Young Kim, Manho Jeon, Daejong Chu, Kon Lee, Sang Kun Clustering of spontaneous recurrent seizures separated by long seizure-free periods: An extended video-EEG monitoring study of a pilocarpine mouse model.